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KMID : 1044820230530060417
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Journal of Periodontal & Implant Science
2023 Volume.53 No. 6 p.417 ~ p.428
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Effect of polydeoxyribonucleotide with xenogeneic collagen matrix on gingival phenotype modification: a pilot preclinical study
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Lim Hyun-Chang
Kim Chang-Hoon
Lee Han-Kyu
Jeon Gye-Won
Herr Yeek
Chung Jong-Hyuk
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Abstract
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Purpose: To investigate the effect of xenogeneic collagen matrix (XCM) with polydeoxyribonucleotide (PDRN) for gingival phenotype modification compared to autogenous connective tissue graft.
Methods: Five mongrel dogs were used in this study. Box-type gingival defects were surgically created bilaterally on the maxillary canines 8 weeks before gingival augmentation.
A coronally positioned flap was performed with either a subepithelial connective tissue graft (SCTG) or XCM with PDRN (2.0 mg/mL). The animals were sacrificed after 12 weeks. Intraoral scanning was performed for soft tissue analysis, and histologic and histomorphometric analyses were performed.
Results: One animal exhibited wound dehiscence, leaving 4 for analysis. Superimposition of STL files revealed no significant difference in the amount of gingival thickness increase (ranging from 0.69±0.25 mm to 0.80±0.31 mm in group SCTG and from 0.48±0.25 mm to 0.85±0.44 mm in group PDRN; P>0.05). Histomorphometric analysis showed no significant differences between the groups in supracrestal gingival tissue height, keratinized tissue height, tissue thickness, and rete peg density (P>0.05).
Conclusions: XCM soaked with PDRN yielded comparable gingival augmentation to SCTG.
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KEYWORD
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Alveolar ridge augmentation, Animal model, Autografts, Polydeoxyribonucleotide, Tissue scaffolds
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